Tsambali limagwiritsa ntchito makeke kukulitsa luso lanu. Mukapitiliza kugwiritsa ntchito tsamba ili mukuvomera MFUNDO yathu ya COOKIE.
Ngati muli ndi nambala ya membala wa ACS, chonde lembani apa kuti tithe kulumikiza akauntiyi ndi umembala wanu. (posankha)
ACS imayamikira zachinsinsi chanu. Potumiza zambiri zanu, mukupeza mwayi wofikira ku C&EN ndikulembetsa kalata yathu yamakalata yamlungu ndi mlungu. Timagwiritsa ntchito zomwe mumapereka kuti tikuthandizeni kuwerenga bwino, ndipo sitingagulitse deta yanu kwa anthu ena.
Njira yabwino yodziwira momwe zimakhalira kufunsa K. Barry Sharpless ndikusewera pinball. Malingaliro ake akakhazikika, simudzadziwa komwe zokambiranazo zifika. Nkhani zokambitsirana zitha kudumpha kuchoka pa usodzi ku gombe la Jersey kupita ku acetylcholinesterase inhibitors kupita ku chiweto chake chokondedwa mutt, Batty, m'mphindi zochepa chabe. Ndipo Sharpless adzakhala woyamba kuvomereza kuti malingaliro ake sakhala ofanana. “Nthaŵi zambiri sindimayankha mafunso,” iye akuvomereza motero. "Sindilankhula ziganizo zonse, ndipo ndili ndi nthawi yolemba bwino."
Priestley Medali wa chaka chino, K. Barry Sharpless, ndi katswiri pakupeza mamolekyu kuti achite zofuna zake. Iye wachita upainiya mbali ziwiri za chemistry: asymmetric catalysis ndikudina chemistry. Ndipo iye anadzoza magulu ankhondo a chemist. Werengani kuti mudziwe momwe wopanga mamolekyuyu adayambira pa usodzi ku Manasquan, New Jersey, mpaka kupambana Mphotho ya Nobel mu Chemistry.
Anzake a Sharpless, ophunzira akale, ndi anzawo onse amafikira mawu ngati "eccentric" ndi "osagwirizana" akafunsidwa kuti amufotokozere. Koma kufotokozera komwe onse amafika ndikuti "amaganiza ngati molekyulu." Mawuwa akuwoneka kuti adachokera kwa Sharpless mwiniwake - adalangiza ophunzira panthawi yake yophunzitsa maphunziro a organic chemistry kuti achite zomwezo. Omwe amadziwa Sharpless akunena mwachidule luso lake lachilendo lodziwa momwe mamolekyu adzachita komanso momwe angawapangire kuti achite zomwe akufuna.
Pantchito yomwe imatenga pafupifupi zaka 50, chidziwitso chamankhwala ichi chapeza Sharpless, yemwe ndi WM Keck Pulofesa wa Chemistry ku Scripps Research ku California, mndandanda wa mphotho - kuphatikiza theka la Mphotho ya Nobel mu Chemistry ya 2001 - yomwe imadzaza masamba awiri agawo limodzi. pa curriculum vitae yake. Chaka chino akuzindikiridwa ndi Mendulo ya Priestley ya 2019, ulemu wapamwamba kwambiri wa American Chemical Society, chifukwa cha "kupangidwa kwa njira zopangira ma oxidation, asymmetric oxidation, lingaliro la chemistry ndikukulitsa mtundu wa copper-catalyzed wa azide-acetylene cycloaddition reaction. ”
"Kulandira Priestley kunandithandiziradi ndipo ndichinthu chomwe sindimayembekezera," akutero Sharpless. Mosiyana ndi a Priestley Medalists ambiri akale, iye sakonda ndale za sayansi komanso kukhala mkonzi wa magazini ya chemistry. Iye anati: “Ndine katswiri wa zamankhwala amene ndathera moyo wanga ndikuyesetsa kuti azitha kuchita bwino pamankhwala opangira mankhwala.
Sharpless sanawoneretu ntchito mu sayansi yapakati. Ngakhale anali wamkulu wa pre-med mpaka semester yake yomaliza ku koleji, adayendetsedwa ndi chikondi chake chapanyanja ndipo adali ndi malingaliro oti akhale kapitawo wa bwato la usodzi - monga amalume ake a Dink, omwe Sharpless amafotokoza kuti ndi nkhosa yakuda. banja.
Sharpless anakulira ku Philadelphia koma adakhala nthawi yachilimwe yaunyamata wake akuyang'ana mtsinje wa Manasquan komwe umakumana ndi gombe la New Jersey. Banja lake linali ndi kanyumba pafupi, ndipo akuti amayi ake amamulola kuti azingoyendayenda. Iye anati: “Kumeneko n’kumene ndinaphunzira za moyo, za chilichonse chimene ndimafuna kuchidziwa. Pamene Sharpless amakula, adayamba kuyenda ndi amalume ake a Dink, akugwira nsomba pa Manasquan.
Sharpless adapita kusukulu ya Quaker ku Philadelphia komwe amavomereza kuti adamuphunzitsa kuwerenga ndi kulankhula Chijeremani (luso lomwe apeza kuti ndi lothandiza pambuyo pake pakuphatikiza zolemba zakale zamakemikolo). Koma akuti nthawi yambiri ankalota masoka asodzi. “Sindinaphunzire zambiri kusukulu kusiyapo zimene ndinafunikira kuchita kuti ndipeze As,” akukumbukira motero.
Sharpless anayamba maphunziro ake a digiri yoyamba ku Dartmouth College mu kugwa kwa 1959. Ali watsopano, iye anathyola mwendo pa ngozi skiing ndipo anakhala nyengo yonse yozizira hobbling ku laibulale pa ndodo kuphunzira organic chemistry. “Sindinangokonda kokha, koma ndimakumbukira zonse,” akutero. “Sindikuganiza kuti panalibe funso limene akanandifunsa limene sindikanatha kuliyankha.”
"Iye anali wophunzira wapamwamba pakati pa 135 Dartmouth omaliza maphunziro a digiri yoyamba mu kosi yoyamba yomwe ndinaphunzitsa mwachindunji nditangomaliza maphunziro a 1960," akutero Tom Spencer, pulofesa wa Dartmouth chemistry emeritus. "Monga wophunzira, ndinalibe chifukwa chodziyerekeza ndi kuyamikira momwe mnyamatayu anali wowoneka bwino komanso wachangu kwambiri, koma mwamwayi sindinamulepheretse kuchita ntchito ya sayansi."
Awa anali masiku omwe malo osungiramo mankhwala anali otseguka kwa ophunzira, Spencer akuti, ndipo Sharpless sakanatha kukana kuyimba kwa siren yamankhwala.
"Anthu ngati ine, tikalowa mu labu, ndiye kuti tili ndi mwayi wokondana," akutero Sharpless. "Ndinaloweza mankhwala onse omwe anali m'chipinda chosungiramo katundu - fungo, kukoma," akutero ndi mawu omwe amachititsa kuti zikhale zovuta kudziwa ngati akuseka. Kaya ali wotsimikiza kapena ayi, kukhalapo kwamtundu woterewu sikoyenera, mopanda chitetezo.
Koma Sharpless sanakhale ku Dartmouth nthawi yachilimwe kuti akafufuze. Iye anati: “Ndinkakonda kwambiri usodzi.
Bambo ake a Sharpless, omwe ndi dokotala wa opaleshoni, “anaganiza kuti Barry apita kusukulu ya udokotala ndipo atsatira mapazi ake,” anatero Spencer. Koma powona talente ya Sharpless mu chemistry, Spencer adamulimbikitsa kuti achite maphunziro apamwamba m'munda. “Tsiku lina atate wake anandiitana nati, ‘Kodi ukutani ndi mnyamata ameneyu? ” Spencer akukumbukira. “Bambo ake ankadabwa kuti ndine yani komanso chifukwa chiyani ndinkafuna kusokoneza moyo wa Barry. Koma nditafotokoza za luso la Barry, bambo ake anakana ndipo pambuyo pake anayamba kumuthandiza kwambiri.”
Kwa omaliza maphunziro awo, Sharpless anasamukira kumadzulo ku yunivesite ya Stanford, komwe ankagwira ntchito za cholesterol biosynthesis ndi Eugene E. van Tamelen monga wophunzira womaliza maphunziro ndi organometallic chemistry ndi James P. Collman monga postdoctoral mnzake. Koma chochititsa chidwi kwambiri chomwe chinachitika pa nthawi ya Sharpless ku Stanford ndi pamene anakumana ndi Jan Dueser paphwando la nyanja. “Jan anali deti la Doug Walgren, mmodzi wa mabwenzi anga a ku Dartmouth,” Sharpless akukumbukira motero.
Awiriwo adatuluka chaka ndi theka pambuyo pake, mu 1965, ndipo Sharpless amamuyamikira pomulimbikitsa komanso kuchita bwino kwake. Mwachitsanzo, zolemba zambiri zomveka bwino zomwe zimawonekera pansi pa mawu a K. Barry Sharpless, monga mbiri ya moyo wake wa Nobel ndi nkhani yofotokoza momwe anataya masomphenya m'diso limodzi panthawi ya kuphulika chifukwa sanali kuvala magalasi otetezera, kwenikweni anali. , lolembedwa ndi Jan.
(Kupatulapo zoseketsa: Walgren adakhala ndi mawu asanu ndi awiri ku US House of Representatives, osankhidwa kuchokera ku Pennsylvania's 18th District. Iye ndi Sharpless anakhalabe mabwenzi, ndipo pamene Sharpless anapambana Nobel Prize mu 2001, Walgren adayitana ndipo Jan anayankha. Anati kwa iye, " Tangoganizani, Jan, ndikadakwatiwa nanu, mwina ndikanakhala purezidenti.)
Mu 1969, Sharpless anasamukira ku Massachusetts kukaphunzira enzymology monga postdoc mu labu ya Konrad E. Bloch pa yunivesite ya Harvard. Chaka chotsatira, adakhala wothandizira pulofesa ku Massachusetts Institute of Technology, komwe adakhala zaka zisanu ndi ziwiri asanagwire ntchito yaukadaulo ku Stanford. Patatha zaka zitatu, adalowanso ku Dipatimenti ya Chemistry ku MIT.
Ku Stanford, Sharpless anali kuyesera kupanga njira zopangira ma asymmetrically oxidize ma bond awiri, kusintha mawonekedwe a C=C kukhala amodzi okha mwa mawonekedwe awiri a 3-D okhala ndi okosijeni. Amakumbukira kuti ntchito yake yaima. "Panali mwezi umodzi nditawauza kuti ndikuchoka kuti ndibwerere ku MIT kuti tidachita bwino kwambiri pa epoxidation ya asymmetric," akutero. Gulu lake likanakhala kuti litatulukira mwezi umodzi m’mbuyomo, iye akuti, “Mwina sindikanachoka.”
Sharpless adawonetsa kufunika kwa asymmetric epoxidation poyigwiritsa ntchito kuti ipange gypsy moth pheromone (+) -disparlure.
Patatha zaka zambiri za chitukuko mu labu ya Sharpless, zomwe iye ndi postdoc wake Tsutomu Katsuki adapeza pomaliza pake anali Sharpless asymmetric epoxidation, yomwe imagwiritsa ntchito titaniyamu ndi ma ligand a chiral kuti asinthe zakumwa zoledzeretsa kukhala 2,3-epoxyalcohols m'njira yosankha. Zomwe zidachitikazi zidawonetsa kuti ndizotheka kugwiritsa ntchito zitsulo m'njira yodziwikiratu kuti ipangitse ma oxidize awiri okhala ndi enantioselectivity yayikulu ndipo inali gawo la ntchito yomwe komiti ya Nobel idatchula. Kuwonetsa momwe zimakhudzidwira, gulu la Sharpless linagwiritsa ntchito kupanga (+) -disparlure, mankhwala omwe njenjete aakazi a gypsy amagwiritsa ntchito ngati zokopa zogonana.
Zikuoneka kuti pheromone ili ndi mphamvu yokhalitsa. Kuwukira kwakukulu kwa njenjete kunachitika ku New England mu 1980, pomwe labu ya Sharpless idasamuka kuchokera ku Stanford kupita ku MIT. Mamembala ena agulu la Sharpless atatsika ndege ku Boston, agulugufe adaukira "zovala zawo zotsuka koma zowoneka bwino" zomwe adavala mu labu panthawi ya (+) -disparlure's synthesis, Jan Sharpless akukumbukira.
Nkhani zakuukira kwa njenjete za gypsy zidafika kwa Kathy Halbreich, yemwe anali mkulu wa Albert ndi Vera List Visual Arts Center ku MIT panthawiyo. Mu 1985, wojambula wamasewera a Thomas Kovachevich akakhala ku MIT, ndipo Halbreich adafunsa Sharpless ngati mgwirizano ungatheke.
Zomwe zidachitikazi zidachitikira muholo yoyimba kwambiri ku MIT. Pamalo akulu akulu apakati pa holoyo, Sharpless ndi Kovachevich anang'amba mapepala aakulu ngati mapepala omwe (+) -kusiyana adagwiritsidwapo ntchito.
"Lingaliro linali loti atulutse njenjete za gypsy pamwamba pa chipindacho ndipo akuwonetsa momwe amapangira mapepalawa omwe amakutidwa ndi pheromone," akutero Rick Danheiser, pulofesa wa chemistry ku MIT.
Ana a njenjete analamulidwa kuchokera ku labotale yofufuza zankhondo kuti adzaswe pa tsiku la sewerolo, Jan akukumbukira. Iye anati: “Anaswa panthaŵi yake, koma n’zomvetsa chisoni kuti mapiko awo aang’onowo anali asanakule mokwanira, motero anyamatawo sanathe kuwuluka. “Osadandaula. Kugonana pokhala momwe zilili, anyamatawo adamasulidwa pamwamba pa kanjira kalikonse ndipo amangogwetsa ndikugwa pansi pamasitepe, kenako anayesa kuwuluka kuchokera pansi kupita papulatifomu. "
Sharpless adachitanso chionetsero chofananira m'kalasi yake yamaphunziro aukadaulo chaka chatha, akukumbukira Danheiser. Pa nthawiyi, mapiko a njenjete amphongo anali atapangana mokwanira, koma (+) -kusiyana kunali kuwomberedwa m'chipinda chonsecho ndi mpweya wabwino. Atangotulutsidwa, njenjete za gypsy zinali kuwuluka paliponse, Danheiser akukumbukira. Iwo anali kutera pa ophunzira, ndipo mantha anadza.
Ngakhale chiwonetsero cha njenjete cha gypsy sichinapite monga momwe adakonzera, Danheiser akuti zinali zowonetsera kaphunzitsidwe ka Sharpless. "Barry nthawi zonse ankayesetsa kupeza njira yosangalatsira kalasi komanso kuchita izi mozindikira," akutero Danheiser. "Chilakolako chake cha chemistry chidawonekera m'maphunziro ake, ndipo chinali chopatsirana."
The asymmetric epoxidation idadzetsa chisangalalo chodabwitsa kuchokera ku chemistry, akutero Eric Jacobsen wa Harvard, yemwe anali postdoc mu labu ya Sharpless kuyambira 1986 mpaka 1988. kwenikweni kuchitapo kanthu koyamba komwe kunalola akatswiri a zamankhwala kuwongolera stereochemistry m'njira yodziwikiratu," akutero.
Pamene Jacobsen anali ku MIT, adagwira ntchito ndi Sharpless pamachitidwe omwe tsopano amadziwika kuti Sharpless asymmetric dihydroxylation. Pakusinthika uku, alkene imakhudzidwa ndi osmium tetroxide pamaso pa chiral quinine ligand kupanga diastereomer imodzi ya vicinal diol, momwe muli magulu awiri -OH pa ma carbons oyandikana nawo. Ichi ndi chimodzi mwazochita za chirally catalyzed oxidation zomwe zidapeza Sharpless Mphotho ya Nobel.
"Barry amasangalala kwambiri ndi zinthu zitamukopa chidwi, koma nthawi zonse sizimamveka bwino kwa anthu omwe ali m'labu kuti zizikhala bwanji," akutero Jacobsen. "Ndinachita mwayi kwambiri chifukwa ndidatha kugwira ntchito yomwe idakopa chidwi chake. Ndipo mutangolandira chidwi chake, zinali zodabwitsa. Zinali zodabwitsa kuti anangodziloŵerera m’vuto n’kutengeka nalo.”
Jacobsen amakumbukira tsiku lina lachiyamiko pa nthawi yake yopita kusukulu pomwe amachezera amayi ake ku New York City. "Foni ikuitana, amayi anga amatenga, ndipo ndi Barry Sharpless," akukumbukira. "Amadziwa mokwanira za kugwira ntchito mu labu kuti adziwe kuti ngati mlangizi wanu akukuyitanani pa Tsiku lakuthokoza, kuyenera kukhala koyipa - pali moto m'chipinda changa kapena china chake." Jacobsen adatenga foniyo mwamantha ndipo adapeza kuti Sharpless amangofuna kulankhula za chemistry. Iye ankangofuna kuti atsatirenso zimene tinkakambirana masiku angapo m’mbuyomo chifukwa sanasiye kuganizira zimenezo.”
Mu 1990 Sharpless anasamukira ku Scripps, atakopeka ndi Richard Lerner, yemwe anali pulezidenti wa bungwe panthawiyo. "Zinali zoonekeratu kuti anali katswiri wamankhwala," akutero Lerner.
Munthawi yake ku Scripps, Sharpless adayamba kusamuka kuchoka ku asymmetric catalysis kupita ku zomwe zitha kukhala chemistry. Lingaliro lapakati pakudina chemistry ndikugwiritsa ntchito midadada yomangira mamolekyulu yomwe imadzaza masika kuti "dinani" limodzi ndi mnzake.
Sharpless ndi Jan adabwera ndikudina chemistry moniker pamodzi. Akuti samaganiza kuti zingachitike, koma zilembo zofananira zakhazikika, ndipo dinani chemistry yayamba kugwiritsidwa ntchito m'malo osiyanasiyana asayansi, kuphatikiza biochemistry, sayansi yazinthu, ndi sayansi yapamtunda.
Ngakhale pali zosintha zingapo zosiyana, chitsanzo choyambirira ndi copper-catalyzed azide-alkyne cycloaddition (CuAAC). Izi zimakwatira azide ndi alkyne kupanga 1,2,3-triazole, yomwe imagwirizanitsa zigawo ziwirizo. Zochita pakati pa azides ndi alkynes sizinali zachilendo. Malipoti a iwo adachokera koyambirira kwa zaka za zana la 20, ndipo Rolf Huisgen waku Ludwig Maximilian University Munich amadziwika kuti adalimbitsa lingaliroli kumapeto kwa zaka za m'ma 1950.
Koma kusintha komwe Huisgen adapanga kunatenga nthawi yayitali, kumafuna kutentha kwambiri, ndikupanga ma regioisomers awiri osiyana - osati momwe Sharpless amasaka. Mu 2002, Sharpless ndi gulu lake adanenanso kuti ngati atagwiritsa ntchito mkuwa (I) kuti apangitse zomwe zikuchitika, atha kuzipangitsa kuti zipite nthawi yomweyo, m'madzi, kutentha, ndipo zimangotulutsa regioisomer imodzi.
Sharpless akuti akatswiri opangira mankhwala sanasangalale ndi chemistry pomwe adayamba kuyankhula za izi. Iye anati: “Zinali zophweka, ndipo zimenezi zinachititsa kuti azinyozetsa. Koma asayansi a mikwingwirima ina anaona mmene kusinthaku kungakhalire kothandiza. Atha kugwiritsa ntchito kutsimikizira kulumikizana kwamitundu yonse. Asayansi apamtunda atha kugwiritsa ntchito chemistry kuti ayimitse molekyulu pamwamba; Akatswiri a sayansi ya zakuthambo angagwiritse ntchito kulumikiza biomolecule pa molekyulu ya mtolankhani. Anthu awa amangofunika chemistry yopanga maubwenzi yomwe imagwira ntchito modalirika komanso pansi pamikhalidwe iliyonse, Sharpless akuti. "Omwe amafunikira ma bond, monga asayansi ndi akatswiri a sayansi ya zinthu zamoyo omwe amafunikira kudziwa zomwe akudziwa kuchokera ku ngalande, samafunsa mafunso. Iwo ali oyamikira kwambiri kukhala ndi chinachake chimene chimagwira ntchito.”
"Click chemistry inali lingaliro la Barry, kudzoza kwake kwathunthu," atero a MG Finn a Georgia Institute of Technology, yemwe adalandira PhD yake mu labu ya Sharpless m'ma 1980s ndipo, monga mnzake ku Scripps, adagwira ntchito ndi Sharpless pakudina chemistry. "Ndikhoza kunyadira pomuthandiza kufotokoza masomphenyawo ndi kulongosola tsatanetsatane wa mfundozo, koma ndinkatsatiradi kutsogolera kwa Barry panjira iliyonse."
Dinani chemistry yakhala chida chothandiza mosakayikira, koma anthu ambiri sanachiwone mwanjira imeneyo poyamba, Jacobsen wa Harvard akuti. Amakumbukira pomwe Sharpless adayamba kukamba za lingalirolo. "Pofika nthawi imeneyo adatulukira zinthu ziwiri zazikulu mu asymmetric catalysis, ndipo analidi chimphona m'munda. Aliyense anali wotsimikiza kuti panthawiyo adzalandira Mphotho ya Nobel, "akutero Jacobsen.
Chifukwa chake Sharpless amapemphedwa kuti apereke maphunziro. "M'malo molankhula za ntchito yake mu asymmetric oxidation, adayamba kunena za lingaliro ili lomwe likuwoneka kuti likuchokera kumanzere," akupitiliza Jacobsen. "Anaganiza kuti zomwe timafunikira ndizochita zabwino. Chinachake chomwe chidzagwirizanitsa zinthu m'njira yodalirika kwathunthu. Umo si momwe akatswiri opangira mankhwala amaganizira nthawi zambiri. Akatswiri a zamankhwala amaganiza, 'Chabwino, nayi molekyulu yomwe ndikufuna kupanga; ndiloleni ndiganizire za njira yabwino yopangira,' kapena 'Nazi zina zomwe ndikufuna kuzimvetsetsa ndikugwiritsa ntchito; ndione chimene ndingachite nacho.' ”
Koma Sharpless anali kunena kuti akatswiri a zamankhwala amafunikira kuchitapo kanthu kodalirika komwe kumagwirizanitsa zinthu m'mikhalidwe yosiyanasiyana. “Ndipo ndimakumbukira omvera akungoyang’anizana kuganiza kuti wasokonezeka maganizo,” akutero Jacobsen. "Ndikufuna kunena kuti panthawiyo ndimadziwa kuti ali pachinthu china, ndimamudziwa bwino ndipo ndidakumana ndi luso lake kotero kuti ndidadziwa kuti anali ndi lingaliro labwino kwambiri. Koma zoona zake n’zakuti, sindikuganiza kuti palibe amene anaona zimene zikubwera. Ndi Sharpless yekha amene adawona kuti lingaliro ili amayenera kupeza mayankho abwino - chilichonse chomwe chingalumikizane ndi zinthu komanso kukhala wamba - chingakhale chosintha mu chemistry.
"Analankhula za izi asanayankhe," akuwonjezera Jacobsen. "Ndipo ndikukumbukira kuti anthu adatsala pang'ono kumukwiyira akamakamba nkhani chifukwa adaitanidwa kuti alankhule za asymmetric catalysis ndipo adayamba kunena za lingaliro lopenga ili, kufotokoza zomwe sanazipeze."
Finn akuvomereza kuti: “Ndithu anthu ambiri ankaganiza kuti anali misala. "Apa anali ndi imodzi mwama labu opangira ma asymmetric catalysis, ndipo kuchokera kunja kumawoneka ngati akufuna kuchita china chake chosiyana. Kenako adanenanso kuti zomwe akufuna kuchita mosiyana ndikuyesera kuphunzitsa akatswiri azamankhwala mwanjira yosiyana kwambiri yochitira sayansi yawo, "akutero. "Ambiri sanamvetse zomwe akunena, kapena kuganiza kuti amvetsetsa ndikuzikana." Koma, Finn akuwonjezera kuti, nthawi yasonyeza kuti lingaliro lake lakhala ndi chiyambukiro chosatsutsika mu sayansi ya mamolekyu.
"Sindikudziwa chifukwa chake wina angaganize kuti Barry anali wamisala, pokhapokha ngati sakusamala zomwe zikuchitika pankhani ya bioorthogonal chemistry ndi biology yamankhwala," akutero Carolyn Bertozzi wa ku Stanford, yemwe adayambitsa kuphatikizika kwa chemistry. “Mwina mbiri ingayang’ane m’mbuyo pa zimene Barry anachita pogwiritsa ntchito mkuwa, kumene kulidi chimodzi mwa zinthu zofunika kwambiri pa sayansi ya zamoyo ndi kutulukira mankhwala osokoneza bongo, monga pamene akatswiri a zamankhwala m’gulu lalikulu la chitukuko cha kachitidwe ka zinthu zopanga potsirizira pake anaphunzira kufunika kokhala kofunika kwa akatswiri a zamoyo. .”
"Barry akufuna kupanga chemistry yomwe ingasinthe dziko kapena kuchita zomwe simukanatha kuchita," akutero a MIT a JoAnne Stubbe, yemwe anali mnzake wa Sharpless kwa zaka zingapo ndipo amakhalabe bwenzi lake. Dinani chemistry ndi umboni wa luso lake, akutero. "Aliyense ndi m'bale wake amagwiritsa ntchito."
Anthu omwe amadziwa Sharpless amanena kuti simungadziwe kuti munthuyo ndi ndani powerenga mapepala ake ndi kuphunzira za sayansi yake. Phil Baran wa Scripps Research akutero Phil Baran wa Scripps Research. Iye ndi wokoma mtima kwambiri komanso wansangala komanso wamanyazi nthawi zina. Amakonda mankhwala kuposa anthu. Kukambitsirana naye kungapitirire kwa maola ambiri ngati simungagwirizane ndi chemistry.”
Gary Siuzdak, yemwe amagwira nawo ntchito ku Scripps, anati: “Kudziwa kwake zinthu zonse zopangidwa ndi zinthu zopanga kumakhala kovuta komanso kochititsa mantha. "Nthawi zambiri zomwe ndimakumbukira za iye zimayamba ndikupita ku ofesi yake kukasiya zinazake mwachangu, kapena kumufunsa malingaliro ake, ndipo mphindi zitatu zidasandulika maola atatu amalingaliro ndi chisangalalo."
Izi sizikutanthauza kuti Sharpless alibe zolakwa zake. Iye angakhale woyamba kuvomereza kuti iye si wokamba nkhani pagulu. Ndipo momwe ubongo wake umalumikizira zingwe zimamuvuta kuti aganizire chinthu chimodzi. Ngakhale kuti ali ndi zophophonya, anzake ndi anzake onse amanena kuti ali ndi mtima wabwino ndipo ndi wowolowa manja pa cholakwa.
Stephen L. Buchwald wa MIT amakumbukira kupita ku ofesi ya Sharpless pazaka zoyambirira za Buchwald monga pulofesa pa sukuluyi. Buchwald adawona kuti Sharpless anali ndi mndandanda wamtengo wapatali wa Comprehensive Organometallic Chemistry, womwe mu 1985 udawononga madola masauzande angapo - ndalama zomwe Sharpless adalipira kuchokera ku ndalama zake. Buchwald akuti adauza Sharpless kuti adachita chidwi kuti ali ndi mndandanda wamtengo wapatali. "Tsiku lotsatira nditalowa muofesi yanga adatenga mndandanda wonse ndikuuyika patebulo langa ndikundipatsa," akutero Buchwald. "Kenako, zidapezeka kuti adazifunanso. Koma m’malo mondipempha kuti ndimubwezere, anagulanso seti ina.”
Mmodzi mwa ophunzira omwe amaliza maphunziro a Sharpless, Gencheng Li, akufotokoza momwe atafika ku Scripps, sankadziwa kusambira. Sharpless atamva izi, adasaina Li up kuti akakhale ndi mphunzitsi wosambira, ndikumuuza kuti sangakhale ku San Diego ndipo sakudziwa kusambira.
Ngakhale Sharpless ali ndi mbiri yoti ndi mphunzitsi, ophunzira ake amati adaphunzira potengera chitsanzo chake. "Kutenga zoopsa kunali kotetezeka nthawi zonse mu labotale ya Barry," akutero Antonella Converso, mkulu wa dipatimenti ya Merck & Co.'s Discovery Chemistry ku West Point, Pennsylvania, yemwe adachita PhD yake ndi Sharpless ku Scripps kuyambira 1998 mpaka 2003. "Mutha kupita nthawi zonse. ndikunena kuti, 'Ndinayesa izi ndipo sizinagwire ntchito,' ndipo sipangakhale zotsatira zoyesa kuchita zinthu mofunitsitsa. Izi zinandiphunzitsa kuti sayansi yabwino siyikuyenda bwino. Sayansi yabwino ili mu malingaliro omwe ali pambali. Muyenera kungoyang'ana maso ndipo musaope kulephera."
"Anthu amati ali ndi chidziwitso chodabwitsa, koma sindikuganiza kuti zimamuchitira chilungamo," a Jacobsen wa Harvard akutero. "Ndikuganiza kuti ndizoposa nzeru. Amadziwa kuganiza m’njira zimene anthu ena sangaziganizire.”
"Wina wochita bwino ngati Barry, ndipo wina yemwe akuwoneka kuti akuchita izi molimbika, amaputa nsanje yambiri mwa omwe amapikisana naye," akutero Julius Rebek, mnzake wakale wa Sharpless komanso mnzake ku Scripps. "Ndikuganiza kuti Barry wawonetsa mobwerezabwereza kuti amabwera ndi zofunikira izi. Njira zake zopangira zinthu zakhalapo ndipo zalemeretsa mibadwo ya akatswiri a zamankhwala.” Mendulo ya Priestley, Rebek akuti, “ndikuzindikirika koyenerera kwa ntchito yake yaikulu ndi utumiki wake ku gulu la mankhwala.”
Nthawi yotumiza: Apr-02-2019